Job Description

Job Summary

The Prensner laboratory (https://prensnerlab.org) at Chad Carr - Pediatric Brain Tumor Center in the Department of Pediatric Oncology and Department of Biological Chemistry is looking for an exceptional candidate for a unique Research Lab Specialist position focused on computational biology and bioinformatics.

This position affords the exciting opportunity to conduct research with cutting-edge sequencing-based data for childhood cancer.  Current interests for the lab include transcriptome assembly, RNA modifications / epitranscriptomics, and protein sequencing in the context of childhood cancer.

Prior work in the lab has focused on the dark genome in cancer (Prensner et al., Nature Biotechnology 2021), gene discovery in pediatric brain cancer (Hofman et al., Molecular Cell, 2024), and small open reading frames (Prensner et al., Molecular & Cellular Proteomics 2023; Mudge, Ruiz-Orera, Prensner et al, Nature Biotechnology 2022).  We have conducted high-depth proteomics analyses of cancer and non-cancer (Deutsch, 2024).  We have employed transformer models for small open reading frames in machine learning studies (Clauwaert et al, 2024).

Responsibilities*

The successful candidate will play a key role in the Prensner laboratory to develop an analytical pipeline for multi-omics datasets in cancer.  This candidate will drive forward research projects utilizing the following sequencing-based data types: ribosome profiling, RNA-sequencing, long read Oxford Nanopore Technology direct RNA sequencing, single cell RNA-seq. The Prensner lab has in-house Illumina and Oxford Nanopore sequencers to generate data rapidly.

In addition, this candidate will be critical to developing a novel bioinformatics approach for single-molecule protein sequencing.  The Prensner Lab is the only location at the University of Michigan and one of ~12 labs nationally that has an in-house protein sequencer for small open reading frame discovery.

This candidate will be expected to contribute to ongoing lab projects in a collaborative nature as well as drive independent research with the goal of publication.  He/she/they will receive commensurate academic credit for these efforts.

PRINCIPAL DUTIES AND RESPONSIBILITIES

Required Qualifications*

Education

Experience

Skills and abilities

Modes of Work

Positions that are eligible for hybrid or mobile/remote work mode are at the discretion of the hiring department. Work agreements are reviewed annually at a minimum and are subject to change at any time, and for any reason, throughout the course of employment. Learn more about the work modes.

Background Screening

Michigan Medicine conducts background screening and pre-employment drug testing on job candidates upon acceptance of a contingent job offer and may use a third party administrator to conduct background screenings.  Background screenings are performed in compliance with the Fair Credit Report Act. Pre-employment drug testing applies to all selected candidates, including new or additional faculty and staff appointments, as well as transfers from other U-M campuses.

Application Deadline

Job openings are posted for a minimum of seven calendar days.  The review and selection process may begin as early as the eighth day after posting. This opening may be removed from posting boards and filled anytime after the minimum posting period has ended.

U-M EEO/AA Statement

The University of Michigan is an equal opportunity/affirmative action employer.

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